FPGS

Across TCGA cell cohorts, FPGS RNA expression is significantly associated with the go_rna of many other GO terms, with 4,894 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FPGS-associated GO terms across cancer lineages are Negative regulation of cilium assembly, Arp2/3 complex-mediated actin nucleation, and Positive regulation of synapse maturation. Each is linked with FPGS in more than 13 cancer types. Because this analysis shows association rather than direction, both FPGS-to-partner and partner-to-FPGS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cilium assembly grouped by FPGS-low versus FPGS-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FPGS→partner) and Y-score (partner→FPGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of cilium assembly →	+0.076	+0.909	.001	.002	3	14
SOFT_TISSUE	Arp2/3 complex-mediated actin nucleation →	+0.091	+0.610	.001	.001	3	13
BONE	Positive regulation of synapse maturation →	+0.238	+0.659	<.001	<.001	3	13
KIDNEY	Response to oscillatory fluid shear stress →	+0.181	+1.097	.001	<.001	3	13
KIDNEY	Cellular response to oscillatory fluid shear stress →	+0.181	+1.097	.001	<.001	3	13
KIDNEY	Vascular endothelial cell response to oscillatory fluid shear stress →	+0.181	+1.097	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,894 associations by consensus.

Negative regulation of cilium assembly by FPGS expression — PANCREAS

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