FPGS

Across TCGA cell cohorts, FPGS mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FPGS-associated genes across cancer lineages are OR8B4, CCDC105, and NPHS2. Each is linked with FPGS in more than 1 cancer types. Because this analysis shows association rather than direction, both FPGS-to-partner and partner-to-FPGS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B4 grouped by FPGS-low versus FPGS-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FPGS→partner) and Y-score (partner→FPGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR8B4 →	+0.036	+4.906	<.001	.006	3	1
BREAST	CCDC105 →	+0.006	+5.169	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	NPHS2 →	+0.013	+4.736	<.001	.009	3	1
LARGE_INTESTINE	MS4A4A →	+0.182	+3.000	<.001	.006	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

OR8B4 by FPGS expression — OESOPHAGUS

Explore this box plot interactively →