FOXS1

Across TCGA patient cohorts, FOXS1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXS1-associated genes across cancer lineages are Akt_pS473, Akt_pT308, and ACC_pS79. Each is linked with FOXS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXS1-to-partner and partner-to-FOXS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pS473 grouped by FOXS1-low versus FOXS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXS1→partner) and Y-score (partner→FOXS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pS473 →	+0.867	+3.169	.015	.019	3	2
UCEC	Akt_pT308 →	+0.730	+3.169	.021	.019	3	2
UCEC	ACC_pS79 →	+0.355	+2.817	.041	.036	3	1
UCEC	IGFBP2 →	-0.881	-2.321	.006	.035	3	1
UCEC	Ku80 →	+0.273	+2.817	.021	.036	3	1
UCEC	Smad3 →	-0.164	-2.321	.030	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Akt_pS473 by FOXS1 expression — UCEC

Explore this box plot interactively →