Across TCGA patient cohorts, FOXR2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXR2-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and eIF4G. Each is linked with FOXR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXR2-to-partner and partner-to-FOXR2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXR2→partner) and Y-score (partner→FOXR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.207	+3.906	.005	<.001	2	3
UCEC	Caspase-7-cleavedD198 →	+0.470	+1.505	.025	.034	3	2
UCEC	eIF4G →	+0.219	+1.700	.046	.042	3	1
UCEC	A-Raf_pS299 →	-0.111	-1.807	.008	.025	3	1
UCEC	INPP4B →	-0.247	-2.584	.030	.010	3	1
UCEC	JNK2 →	+0.142	+1.362	.042	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

FOXR2 survival (RNA) · tumor vs normal (RNA) · all FOXR2 data types