Across TCGA cell cohorts, FOXR2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXR2-associated genes across cancer lineages are SH3GL2, APLNR, and MSGN1. Each is linked with FOXR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXR2-to-partner and partner-to-FOXR2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXR2→partner) and Y-score (partner→FOXR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.652	+3.474	<.001	.003	3	1
LARGE_INTESTINE	APLNR →	+0.218	+3.799	.002	.003	3	1
LARGE_INTESTINE	MSGN1 →	+0.069	+3.345	<.001	.001	3	1
LARGE_INTESTINE	C8A →	+0.020	+3.099	<.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.209	+2.688	.003	.008	3	1
LARGE_INTESTINE	SPRR2F →	+0.410	+3.292	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

FOXR2 survival (RNA) · tumor vs normal (RNA) · all FOXR2 data types