FOXQ1

Across TCGA patient cohorts, FOXQ1 mutation is significantly associated with the RNA expression of many other genes, with 413 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXQ1-associated genes across cancer lineages are C9orf62, RN7SL83P, and CCDC182. Each is linked with FOXQ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXQ1-to-partner and partner-to-FOXQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf62 grouped by FOXQ1-low versus FOXQ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXQ1→partner) and Y-score (partner→FOXQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C9orf62 →	+0.079	+2.567	.001	.008	3	2
COAD	RN7SL83P →	+0.554	+6.392	<.001	.001	3	2
BLCA	CCDC182 →	+0.044	+2.913	.009	.002	3	1
BLCA	H2BU2P →	+0.358	+2.816	.004	.005	3	1
BLCA	RNU6ATAC4P →	+0.244	+2.913	<.001	.002	3	1
UCEC	RNU6-6P →	+0.522	+2.075	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 413 associations by consensus.

C9orf62 by FOXQ1 expression — UCEC

Explore this box plot interactively →