FOXQ1

Across TCGA patient cohorts, FOXQ1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXQ1-associated genes across cancer lineages are ER-alpha, YAP_pS127, and JNK_pT183_Y185. Each is linked with FOXQ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXQ1-to-partner and partner-to-FOXQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by FOXQ1-low versus FOXQ1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXQ1→partner) and Y-score (partner→FOXQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ER-alpha →	+0.232	+3.017	.037	.019	3	1
BLCA	YAP_pS127 →	-0.475	-3.000	.021	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.196	-2.986	.044	.037	3	1
UCEC	Annexin-1 →	+1.160	+2.827	<.001	.035	3	1
BLCA	MEK1 →	-0.250	-2.982	.040	.036	2	1
UCEC	PDCD4 →	-0.919	-3.000	<.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ER-alpha by FOXQ1 expression — BLCA

Explore this box plot interactively →