FOXQ1

Across TCGA cell cohorts, FOXQ1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible FOXQ1-associated genes across cancer lineages are RNASE8, DCDC2C, and ACSM6. Each is linked with FOXQ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXQ1-to-partner and partner-to-FOXQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE8 grouped by FOXQ1-low versus FOXQ1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXQ1→partner) and Y-score (partner→FOXQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RNASE8 →	+0.045	+4.584	<.001	.002	3	1
URINARY_TRACT	DCDC2C →	+0.126	+4.217	<.001	.005	3	1
LARGE_INTESTINE	ACSM6 →	+0.025	+3.584	<.001	.002	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1
CNS	SCGB1C1 →	+0.201	+4.981	<.001	.008	3	1
CNS	OR4D2 →	+0.020	+6.357	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

RNASE8 by FOXQ1 expression — URINARY_TRACT

Explore this box plot interactively →