FOXP4

Across TCGA patient cohorts, FOXP4 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,244 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible FOXP4-associated proteins across cancer lineages are FOXP4_S554, ZNF318_S1243, and BCL11A_S432. Each is linked with FOXP4 in more than 6 cancer types. Because this analysis shows association rather than direction, both FOXP4-to-partner and partner-to-FOXP4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FOXP4 versus FOXP4_S554 in PDAC, with a Pearson correlation of 0.52.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXP4→partner) and Y-score (partner→FOXP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FOXP4_S554 →	+0.707	+0.751	<.001	<.001	3	7
LSCC	ZNF318_S1243 →	+0.579	+0.806	<.001	<.001	3	5
LUAD	BCL11A_S432 →	+0.869	+0.739	<.001	<.001	3	4
UCEC	DNMT3A →	+0.477	+0.859	<.001	<.001	3	4
LSCC	GMPPB →	-0.280	-0.567	.007	.003	3	4
GBM	SMC1A →	+0.325	+0.463	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,244 associations by consensus.

FOXP4 vs FOXP4_S554 — PDAC

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