FOXP4

Across TCGA patient cohorts, FOXP4 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXP4-associated genes across cancer lineages are PKC-a_pS657, GAPDH, and mTOR_pS2448. Each is linked with FOXP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXP4-to-partner and partner-to-FOXP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-a_pS657 grouped by FOXP4-low versus FOXP4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXP4→partner) and Y-score (partner→FOXP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PKC-a_pS657 →	-0.464	-3.169	.027	.019	3	2
UCEC	GAPDH →	+0.547	+2.906	.003	.001	3	2
UCEC	mTOR_pS2448 →	-0.139	-2.202	.008	.010	3	2
UCEC	ATM →	-0.599	-2.874	<.001	<.001	3	2
SKCM	PKC-a →	-0.477	-3.169	.031	.019	3	1
UCEC	eEF2 →	+0.370	+2.000	.003	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PKC-a_pS657 by FOXP4 expression — SKCM

Explore this box plot interactively →