FOXP4

Across TCGA cell cohorts, FOXP4 mutation is significantly associated with the RNA expression of many other genes, with 720 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXP4-associated genes across cancer lineages are ACOT8, RAB3A, and KXD1. Each is linked with FOXP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXP4-to-partner and partner-to-FOXP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACOT8 grouped by FOXP4-low versus FOXP4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXP4→partner) and Y-score (partner→FOXP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACOT8 →	-0.812	-3.169	<.001	.009	3	1
LARGE_INTESTINE	RAB3A →	+0.922	+3.299	.001	.004	3	1
LARGE_INTESTINE	KXD1 →	+0.421	+3.299	.002	.004	3	1
LARGE_INTESTINE	PMP22 →	+1.365	+3.212	.009	.006	3	1
LARGE_INTESTINE	CYP27B1 →	+0.827	+3.212	.002	.006	3	1
LARGE_INTESTINE	GPR63 →	+1.036	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 720 associations by consensus.

ACOT8 by FOXP4 expression — LARGE_INTESTINE

Explore this box plot interactively →