FOXP3

Across TCGA patient cohorts, FOXP3 mutation is significantly associated with the RNA expression of many other genes, with 4,281 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXP3-associated genes across cancer lineages are KIF18BP1, RNU6-605P, and LINC02488. Each is linked with FOXP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXP3-to-partner and partner-to-FOXP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF18BP1 grouped by FOXP3-low versus FOXP3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXP3→partner) and Y-score (partner→FOXP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIF18BP1 →	+0.463	+4.032	<.001	.003	3	2
LUAD	RNU6-605P →	+0.275	+3.999	.005	.005	3	2
LUAD	LINC02488 →	+0.053	+4.303	<.001	.009	3	2
LUAD	RNU6-1108P →	+0.259	+6.014	<.001	<.001	3	2
UCEC	HNRNPCL3 →	+0.031	+1.871	<.001	.003	3	2
COAD	CDK8P1 →	+0.388	+4.611	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,281 associations by consensus.

KIF18BP1 by FOXP3 expression — BRCA

Explore this box plot interactively →