FOXP3

Across TCGA patient cohorts, FOXP3 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXP3-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with FOXP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXP3-to-partner and partner-to-FOXP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by FOXP3-low versus FOXP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXP3→partner) and Y-score (partner→FOXP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.217	+1.662	.004	.011	3	2
UCEC	Caspase-7-cleavedD198 →	+0.586	+1.505	.005	.034	3	2
UCEC	14-3-3_beta →	-0.073	-2.432	.039	.018	3	1
UCEC	EGFR_pY1068 →	-0.251	-2.000	.004	.003	3	1
UCEC	A-Raf_pS299 →	-0.109	-2.222	.009	.010	3	1
UCEC	IRS1 →	+0.149	+1.662	.042	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PCNA by FOXP3 expression — UCEC

Explore this box plot interactively →