FOXP3

Across TCGA cell cohorts, FOXP3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FOXP3-associated genes across cancer lineages are UCP1, HHLA1, and DPT. Each is linked with FOXP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXP3-to-partner and partner-to-FOXP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UCP1 grouped by FOXP3-low versus FOXP3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXP3→partner) and Y-score (partner→FOXP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UCP1 →	+0.172	+3.999	.006	.005	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	DPT →	+1.503	+3.769	<.001	.008	3	1
BLOOD_Leukemia	GPR101 →	+0.106	+3.551	<.001	.009	3	1
BLOOD_Leukemia	OXGR1 →	+0.132	+3.847	<.001	.007	3	1
BLOOD_Leukemia	CLCA4 →	+0.156	+4.822	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

UCP1 by FOXP3 expression — BLOOD_Leukemia

Explore this box plot interactively →