FOXP3

Across TCGA cell cohorts, FOXP3 mutation is significantly associated with the mutation status of many other genes, with 962 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FOXP3-associated genes across cancer lineages are ZNF544, PRKD2, and TAX1BP1. Each is linked with FOXP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXP3-to-partner and partner-to-FOXP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF544 grouped by FOXP3-low versus FOXP3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXP3→partner) and Y-score (partner→FOXP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF544 →	+4.560	+4.870	<.001	<.001	1	3
BLOOD_Leukemia	PRKD2 →	+2.975	+3.794	.006	.006	1	2
BLOOD_Leukemia	TAX1BP1 →	+5.145	+5.145	<.001	<.001	1	2
BLOOD_Leukemia	NFKB1 →	+3.338	+4.083	.003	.003	1	2
BLOOD_Leukemia	ONECUT2 →	+4.145	+4.635	.001	.001	1	2
BLOOD_Leukemia	ZC2HC1C →	+6.145	+5.479	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 962 associations by consensus.

ZNF544 by FOXP3 expression — BLOOD_Leukemia

Explore this box plot interactively →