FOXP2

Across TCGA patient cohorts, FOXP2 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXP2-associated genes across cancer lineages are mTOR_pS2448, ASNS, and MEK1. Each is linked with FOXP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXP2-to-partner and partner-to-FOXP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by FOXP2-low versus FOXP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXP2→partner) and Y-score (partner→FOXP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.138	-2.489	.002	.001	3	3
UCEC	ASNS →	+0.291	+1.584	.008	.032	3	3
UCEC	MEK1 →	+0.375	+2.502	<.001	.001	3	2
COAD	PCNA →	+0.274	+3.178	.024	.010	3	2
UCEC	A-Raf_pS299 →	-0.109	-2.222	.002	.009	3	2
UCEC	p62 Lck ligand →	+0.347	+2.257	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

mTOR_pS2448 by FOXP2 expression — UCEC

Explore this box plot interactively →