FOXP2

Across TCGA cell cohorts, FOXP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,040 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FOXP2-associated GO terms across cancer lineages are Regulation of transcription by RNA polymerase I, Regulation of smooth muscle cell-matrix adhesion, and Subpallium development. Each is linked with FOXP2 in more than 6 cancer types. Because this analysis shows association rather than direction, both FOXP2-to-partner and partner-to-FOXP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription by RNA polymerase I grouped by FOXP2-low versus FOXP2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXP2→partner) and Y-score (partner→FOXP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of transcription by RNA polymerase I →	+0.110	+1.755	<.001	<.001	3	7
LUNG_NSCLC_LUAD	Regulation of smooth muscle cell-matrix adhesion →	-0.569	-0.952	.006	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Subpallium development →	-0.204	-0.709	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Striatum development →	-0.204	-0.709	<.001	<.001	3	7
SOFT_TISSUE	Cerebellar Purkinje cell layer development →	-0.089	-1.223	<.001	.003	3	7
SOFT_TISSUE	RNA polymerase II transcription initiation surveillance →	+0.092	+1.736	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,040 associations by consensus.

Regulation of transcription by RNA polymerase I by FOXP2 expression — SOFT_TISSUE

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