FOXP2

Across TCGA cell cohorts, FOXP2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FOXP2-associated genes across cancer lineages are OR2L8, DMRTC2, and ZNF804B. Each is linked with FOXP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXP2-to-partner and partner-to-FOXP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by FOXP2-low versus FOXP2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXP2→partner) and Y-score (partner→FOXP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2L8 →	+0.015	+5.266	<.001	.001	3	2
BLOOD_Lymphoma	DMRTC2 →	+0.009	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	ZNF804B →	+0.019	+4.350	<.001	.005	3	1
LARGE_INTESTINE	FAM243A →	+0.260	+3.404	<.001	.006	3	1
SKIN	MAGEB4 →	+0.008	+4.437	<.001	.004	3	1
SKIN	P2RY10 →	+0.065	+4.263	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR2L8 by FOXP2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →