FOXO3

Across TCGA pan-cancer cohorts, FOXO3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FOXO3 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FOXO3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FOXO3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC and LUAD are the cancer types where FOXO3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.991	0.679	<.001	56	view →
LUAD	DFS	Median	All	0.758	0.483	.004	20	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

FOXO3–PDAC (DFS)

Open the PDAC breakdown →