FOXO3

Across TCGA patient cohorts, FOXO3 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,237 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible FOXO3-associated proteins across cancer lineages are FOXO3_S253, FOXO3_S284, and ARID1B. Each is linked with FOXO3 in more than 5 cancer types. Because this analysis shows association rather than direction, both FOXO3-to-partner and partner-to-FOXO3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FOXO3 versus FOXO3_S253 in BRCA, with a Pearson correlation of 0.56.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXO3→partner) and Y-score (partner→FOXO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FOXO3_S253 →	+0.730	+0.666	<.001	<.001	3	6
UCEC	FOXO3_S284 →	+0.544	+0.439	<.001	<.001	3	5
HNSC	ARID1B →	+0.230	+0.595	<.001	.008	3	5
BRCA	FOXO3_S413 →	+0.638	+0.639	<.001	<.001	3	5
OV	VTA1 →	+0.414	+0.812	.001	.002	3	4
OV	PREP →	+0.292	+0.710	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,237 associations by consensus.

FOXO3 vs FOXO3_S253 — BRCA

Explore this scatter interactively →