FOXO3

Across TCGA patient cohorts, FOXO3 protein abundance is significantly associated with the RNA expression of many other genes, with 4,336 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible FOXO3-associated genes across cancer lineages are CDK19, NCOA7, and ZBTB24. Each is linked with FOXO3 in more than 4 cancer types. Because this analysis shows association rather than direction, both FOXO3-to-partner and partner-to-FOXO3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FOXO3 versus CDK19 in BRCA, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXO3→partner) and Y-score (partner→FOXO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDK19 →	+0.653	+0.355	<.001	<.001	3	5
OV	NCOA7 →	+0.754	+0.345	.001	.001	3	4
BRCA	ZBTB24 →	+0.476	+0.360	<.001	<.001	3	4
BRCA	ARMC2 →	+0.608	+0.412	<.001	<.001	3	4
BRCA	PNISR →	+0.518	+0.302	<.001	<.001	3	4
BRCA	PNRC1 →	+0.579	+0.324	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,336 associations by consensus.

FOXO3 vs CDK19 — BRCA

Explore this scatter interactively →