FOXO3

Across TCGA patient cohorts, FOXO3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXO3-associated genes across cancer lineages are c-Met_pY1235, STAT3_pY705, and ATM. Each is linked with FOXO3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXO3-to-partner and partner-to-FOXO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by FOXO3-low versus FOXO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXO3→partner) and Y-score (partner→FOXO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.068	+1.512	.005	.017	3	3
UCEC	STAT3_pY705 →	-0.313	-2.321	<.001	.005	3	2
UCEC	ATM →	-0.628	-3.986	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.244	-2.115	.003	.016	3	1
UCEC	A-Raf_pS299 →	-0.144	-2.087	<.001	.005	3	1
UCEC	ERK2 →	+0.196	+1.652	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

c-Met_pY1235 by FOXO3 expression — UCEC

Explore this box plot interactively →