FOXO3

Across TCGA cell cohorts, FOXO3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,551 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FOXO3-associated GO terms across cancer lineages are Positive regulation of muscle adaptation, Regulation of muscle atrophy, and Response to nerve growth factor. Each is linked with FOXO3 in more than 19 cancer types. Because this analysis shows association rather than direction, both FOXO3-to-partner and partner-to-FOXO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of muscle adaptation grouped by FOXO3-low versus FOXO3-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXO3→partner) and Y-score (partner→FOXO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Positive regulation of muscle adaptation →	+1.296	+1.282	<.001	<.001	3	20
SOFT_TISSUE	Regulation of muscle atrophy →	+0.293	+0.726	.005	<.001	3	18
STOMACH	Response to nerve growth factor →	+0.091	+1.177	<.001	<.001	3	13
STOMACH	Cellular response to nerve growth factor stimulus →	+0.093	+1.115	<.001	<.001	2	14
STOMACH	Positive regulation of cytoplasmic translation →	+0.169	+1.441	<.001	<.001	3	12
STOMACH	Cellular response to nutrient levels →	+0.057	+1.341	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,551 associations by consensus.

Positive regulation of muscle adaptation by FOXO3 expression — LUNG_NSCLC_LUAD

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