FOXO1

Across TCGA cell cohorts, FOXO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,712 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FOXO1-associated GO terms across cancer lineages are Negative regulation of stress-activated protein kinase signaling cascade, Positive regulation of cytoplasmic mRNA processing body assembly, and Positive regulation of lamellipodium morphogenesis. Each is linked with FOXO1 in more than 10 cancer types. Because this analysis shows association rather than direction, both FOXO1-to-partner and partner-to-FOXO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of stress-activated protein kinase signaling cascade grouped by FOXO1-low versus FOXO1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXO1→partner) and Y-score (partner→FOXO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Negative regulation of stress-activated protein kinase signaling cascade →	-0.120	-0.833	<.001	<.001	3	11
BLOOD_Lymphoma	Positive regulation of cytoplasmic mRNA processing body assembly →	+0.124	+2.448	<.001	<.001	3	10
LIVER	Positive regulation of lamellipodium morphogenesis →	+0.159	+1.668	.004	.001	3	10
URINARY_TRACT	Negative regulation of stem cell differentiation →	+0.108	+0.998	.002	<.001	3	9
LUNG_NSCLC_LUAD	Negative regulation of stress-activated MAPK cascade →	-0.106	-0.656	.001	.001	3	9
BLOOD_Myeloma	Regulation of cytoplasmic mRNA processing body assembly →	+0.083	+1.420	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,712 associations by consensus.

Negative regulation of stress-activated protein kinase signaling cascade by FOXO1 expression — LUNG_NSCLC_LUAD

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