FOXO1

Across TCGA cell cohorts, FOXO1 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FOXO1-associated genes across cancer lineages are MTO1, CPO, and MS4A2. Each is linked with FOXO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXO1-to-partner and partner-to-FOXO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTO1 grouped by FOXO1-low versus FOXO1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXO1→partner) and Y-score (partner→FOXO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MTO1 →	+0.683	+3.125	.003	.008	3	1
LARGE_INTESTINE	CPO →	+0.105	+3.777	.001	.001	3	1
LARGE_INTESTINE	MS4A2 →	+0.016	+2.518	<.001	.006	3	1
LARGE_INTESTINE	GP9 →	+0.055	+3.196	.009	<.001	3	1
LARGE_INTESTINE	LPAR3 →	+1.530	+3.215	<.001	.009	3	1
LARGE_INTESTINE	TCERG1L →	+0.055	+3.584	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

MTO1 by FOXO1 expression — LARGE_INTESTINE

Explore this box plot interactively →