FOXN4

Across TCGA pan-cancer cohorts, FOXN4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FOXN4 data layer compared with 18 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher FOXN4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FOXN4 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUSC, COAD, and LUAD are the cancer types where FOXN4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.249	0.635	.006	17	view →
COAD	OS	Median	All	0.001	0.871	<.001	12	view →
LUAD	DFS	Median	All	1.000	0.332	.026	11	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FOXN4–LUSC (OS)

Open the LUSC breakdown →