FOXN4

Across TCGA patient cohorts, FOXN4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXN4-associated genes across cancer lineages are HER3_pY1289, mTOR_pS2448, and Notch1. Each is linked with FOXN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXN4-to-partner and partner-to-FOXN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by FOXN4-low versus FOXN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXN4→partner) and Y-score (partner→FOXN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.145	+3.341	<.001	.005	3	2
UCEC	mTOR_pS2448 →	-0.185	-3.150	.005	.019	3	2
UCEC	Notch1 →	+0.255	+3.331	<.001	.005	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.489	-3.321	.015	.010	3	2
UCEC	Smad3 →	+0.143	+2.000	.034	.032	3	2
UCEC	STAT3_pY705 →	-0.247	-2.449	.036	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

HER3_pY1289 by FOXN4 expression — UCEC

Explore this box plot interactively →