FOXN4

Across TCGA cell cohorts, FOXN4 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FOXN4-associated genes across cancer lineages are MMP26, HTR1E, and OR56A1. Each is linked with FOXN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXN4-to-partner and partner-to-FOXN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by FOXN4-low versus FOXN4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXN4→partner) and Y-score (partner→FOXN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MMP26 →	+0.026	+6.022	<.001	.001	3	1
SKIN	HTR1E →	+0.036	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR56A1 →	+0.396	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR56A4 →	+0.219	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.036	+5.813	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR4D10 →	+0.039	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MMP26 by FOXN4 expression — SKIN

Explore this box plot interactively →