Across TCGA pan-cancer cohorts, FOXN3P2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of FOXN3P2’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where FOXN3P2 RNA is repressed in tumor relative to normal tissue. In most cancer types FOXN3P2 is over-expressed in tumor, although a few such as BRCA and HNSC show the opposite, repressed pattern.
BRCA and HNSC are the cancer types where FOXN3P2 tumor–normal differential expression is most reproducible.