Across TCGA pan-cancer cohorts, FOXN3P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of FOXN3P1’s most consistent transcriptional readouts.
The strongest signal is observed in rectum adenocarcinoma (READ), where FOXN3P1 RNA is repressed in tumor relative to normal tissue. In most cancer types FOXN3P1 is over-expressed in tumor, although a few such as READ and STAD show the opposite, repressed pattern.
READ and STAD are the cancer types where FOXN3P1 tumor–normal differential expression is most reproducible.