FOXN3

Across TCGA patient cohorts, FOXN3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXN3-associated genes across cancer lineages are STAT3_pY705, ATM, and eIF4E. Each is linked with FOXN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXN3-to-partner and partner-to-FOXN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by FOXN3-low versus FOXN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXN3→partner) and Y-score (partner→FOXN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.231	-0.999	.002	.042	3	3
UCEC	ATM →	-0.421	-1.912	.001	.004	3	2
UCEC	eIF4E →	+0.152	+2.920	.012	<.001	3	1
UCEC	eIF4G →	+0.221	+2.321	.013	.005	3	1
UCEC	GATA6 →	-0.108	-1.056	.022	.047	3	1
UCEC	ACC1 →	+0.214	+0.999	.040	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

STAT3_pY705 by FOXN3 expression — UCEC

Explore this box plot interactively →