FOXN3

Across TCGA cell cohorts, FOXN3 mutation is significantly associated with the RNA expression of many other genes, with 121 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXN3-associated genes across cancer lineages are NRSN1, CACNG2, and BTNL3. Each is linked with FOXN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXN3-to-partner and partner-to-FOXN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NRSN1 grouped by FOXN3-low versus FOXN3-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXN3→partner) and Y-score (partner→FOXN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NRSN1 →	+0.318	+3.869	.001	.002	3	1
PANCREAS	CACNG2 →	+0.375	+3.426	.003	.003	3	1
PANCREAS	BTNL3 →	+0.299	+3.959	<.001	.004	3	1
PANCREAS	ISX →	+0.783	+4.468	<.001	<.001	3	1
PANCREAS	ARGFX →	+0.021	+3.554	<.001	.003	3	1
PANCREAS	SCRT2 →	+0.450	+3.554	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 121 associations by consensus.

NRSN1 by FOXN3 expression — PANCREAS

Explore this box plot interactively →