FOXM1

Across TCGA patient cohorts, FOXM1 mutation is significantly associated with the RNA expression of many other genes, with 1,303 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXM1-associated genes across cancer lineages are GHITM, CLPX, and PDE12. Each is linked with FOXM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXM1-to-partner and partner-to-FOXM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHITM grouped by FOXM1-low versus FOXM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXM1→partner) and Y-score (partner→FOXM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GHITM →	+0.528	+2.861	.001	.001	3	3
UCEC	CLPX →	+0.389	+2.661	.005	.004	3	3
UCEC	PDE12 →	+0.491	+2.332	<.001	.003	3	3
UCEC	DBF4 →	+0.500	+2.136	.003	.009	3	3
HNSC	PSMB7P1 →	+0.070	+4.655	.001	.007	3	3
COAD	HIGD1AP9 →	+0.176	+3.321	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,303 associations by consensus.

GHITM by FOXM1 expression — UCEC

Explore this box plot interactively →