FOXM1

Across TCGA patient cohorts, FOXM1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXM1-associated genes across cancer lineages are Cyclin-E2, Bcl-2, and EGFR_pY1173. Each is linked with FOXM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXM1-to-partner and partner-to-FOXM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by FOXM1-low versus FOXM1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXM1→partner) and Y-score (partner→FOXM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Cyclin-E2 →	+0.200	+2.845	.035	.033	3	3
UCEC	Bcl-2 →	-0.314	-2.095	.013	.017	3	3
UCEC	EGFR_pY1173 →	+0.072	+2.321	.013	.033	3	2
UCEC	eIF4G →	+0.224	+1.807	.049	.025	3	2
UCEC	FOXO3a_pS318_S321 →	-0.108	-2.690	.018	.006	3	2
UCEC	p38-MAPK →	-0.145	-1.979	.016	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Cyclin-E2 by FOXM1 expression — BLCA

Explore this box plot interactively →