FOXM1

Across TCGA cell cohorts, FOXM1 mutation is significantly associated with the RNA expression of many other genes, with 468 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXM1-associated genes across cancer lineages are KRTAP1-4, GCAT, and TNRC6B. Each is linked with FOXM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXM1-to-partner and partner-to-FOXM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP1-4 grouped by FOXM1-low versus FOXM1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXM1→partner) and Y-score (partner→FOXM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KRTAP1-4 →	+0.096	+5.087	<.001	.004	3	1
LARGE_INTESTINE	GCAT →	+1.199	+3.169	.003	.009	3	1
LARGE_INTESTINE	TNRC6B →	+0.792	+3.364	<.001	.002	3	1
LARGE_INTESTINE	IFT27 →	+0.799	+3.451	.005	.002	3	1
LARGE_INTESTINE	CTSZ →	-1.416	-3.169	<.001	.009	3	1
LARGE_INTESTINE	METTL4 →	+0.746	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 468 associations by consensus.

KRTAP1-4 by FOXM1 expression — URINARY_TRACT

Explore this box plot interactively →