Across TCGA pan-cancer cohorts, FOXL2NB RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FOXL2NB’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FOXL2NB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FOXL2NB is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.
HNSC, THCA, and BLCA are the cancer types where FOXL2NB tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOXL2NB RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.