Across TCGA patient cohorts, FOXL2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. COAD shows the largest number of these associations.

The most reproducible FOXL2-associated genes across cancer lineages are LKB1, c-Met_pY1235, and Notch1. Each is linked with FOXL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXL2-to-partner and partner-to-FOXL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXL2→partner) and Y-score (partner→FOXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LKB1 →	+0.165	+2.815	.002	.036	3	2
COAD	c-Met_pY1235 →	+0.184	+2.849	<.001	.034	3	2
COAD	Notch1 →	+0.215	+2.815	.034	.036	3	1
COAD	RAD51 →	+0.177	+2.815	.041	.036	3	1
COAD	Cyclin-E2 →	+0.335	+2.815	.008	.036	1	2
COAD	AR →	+0.205	+2.815	.041	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

FOXL2 survival (RNA) · tumor vs normal (RNA) · all FOXL2 data types