FOXK2

Across TCGA patient cohorts, FOXK2 mutation is significantly associated with the RNA expression of many other genes, with 888 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXK2-associated genes across cancer lineages are MIR7974, RNY1P2, and RNU6-43P. Each is linked with FOXK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXK2-to-partner and partner-to-FOXK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7974 grouped by FOXK2-low versus FOXK2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXK2→partner) and Y-score (partner→FOXK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR7974 →	+0.632	+3.671	.004	.007	3	3
COAD	RNY1P2 →	+0.149	+4.927	.003	.002	3	3
SKCM	RNU6-43P →	+0.185	+2.480	<.001	.005	3	3
THCA	RNA5SP471 →	+0.334	+7.962	<.001	.007	3	2
SARC	PPIAP17 →	+0.198	+5.477	<.001	.004	3	2
SARC	FAM96AP1 →	+0.113	+5.111	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 888 associations by consensus.

MIR7974 by FOXK2 expression — BLCA

Explore this box plot interactively →