FOXK2

Across TCGA patient cohorts, FOXK2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXK2-associated genes across cancer lineages are S6_pS240_S244, ASNS, and EGFR_pY1068. Each is linked with FOXK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXK2-to-partner and partner-to-FOXK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by FOXK2-low versus FOXK2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXK2→partner) and Y-score (partner→FOXK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	S6_pS240_S244 →	+0.605	+3.000	.011	.036	3	2
SKCM	ASNS →	+0.549	+3.000	.027	.036	3	2
UCEC	EGFR_pY1068 →	-0.262	-1.584	.007	.036	3	2
UCEC	eIF4E →	+0.232	+3.335	.004	.005	3	2
UCEC	mTOR_pS2448 →	-0.126	-1.584	.032	.036	3	2
UCEC	STAT3_pY705 →	-0.336	-2.502	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

S6_pS240_S244 by FOXK2 expression — SKCM

Explore this box plot interactively →