FOXK2

Across TCGA cell cohorts, FOXK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,697 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FOXK2-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Negative regulation of gene expression, epigenetic, and Heterochromatin formation. Each is linked with FOXK2 in more than 16 cancer types. Because this analysis shows association rather than direction, both FOXK2-to-partner and partner-to-FOXK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by FOXK2-low versus FOXK2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXK2→partner) and Y-score (partner→FOXK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.063	+0.588	.002	.001	3	17
STOMACH	Negative regulation of gene expression, epigenetic →	+0.078	+0.875	<.001	<.001	3	16
OVARY	Heterochromatin formation →	+0.071	+0.802	<.001	<.001	3	16
URINARY_TRACT	mRNA alternative polyadenylation →	+0.082	+0.732	.002	<.001	3	15
BONE	Subtelomeric heterochromatin formation →	+0.117	+0.669	<.001	<.001	3	15
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.158	+0.684	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,697 associations by consensus.

Epigenetic regulation of gene expression by FOXK2 expression — LUNG_SCLC

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