FOXK2

Across TCGA cell cohorts, FOXK2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXK2-associated genes across cancer lineages are HMHB1, OR6N1, and GAGE12G. Each is linked with FOXK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXK2-to-partner and partner-to-FOXK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMHB1 grouped by FOXK2-low versus FOXK2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXK2→partner) and Y-score (partner→FOXK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HMHB1 →	+0.076	+6.022	<.001	.001	3	1
SKIN	OR6N1 →	+0.257	+5.415	<.001	.004	3	1
SKIN	GAGE12G →	+0.368	+4.977	<.001	.007	3	1
BLOOD_Leukemia	DRD3 →	+0.014	+4.201	<.001	.001	3	1
BLOOD_Leukemia	CYP2A13 →	+0.006	+4.569	<.001	.003	3	1
BLOOD_Leukemia	ARSH →	+0.011	+3.922	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

HMHB1 by FOXK2 expression — SKIN

Explore this box plot interactively →