FOXJ2

Across TCGA patient cohorts, FOXJ2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXJ2-associated genes across cancer lineages are eIF4E, PCNA, and Annexin-1. Each is linked with FOXJ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXJ2-to-partner and partner-to-FOXJ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FOXJ2-low versus FOXJ2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXJ2→partner) and Y-score (partner→FOXJ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.165	+3.598	.027	.001	3	2
UCEC	PCNA →	+0.231	+2.700	.002	.005	3	2
UCEC	Annexin-1 →	+0.622	+2.341	<.001	.003	3	2
UCEC	Src_pY416 →	-0.196	-1.649	.021	.011	3	2
UCEC	ATM →	-0.410	-1.861	.010	.049	3	2
UCEC	Di-Ras3 →	-0.118	-1.662	.024	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eIF4E by FOXJ2 expression — UCEC

Explore this box plot interactively →