FOXJ1

Across TCGA pan-cancer cohorts, FOXJ1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FOXJ1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FOXJ1 RNA is repressed in tumor relative to normal tissue. In most cancer types FOXJ1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where FOXJ1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOXJ1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−3.621	<.001	11	view →
THCA	Male	III,IV	−3.597	<.001	11	view →
KIRC	Male	II,III,IV	−2.416	<.001	11	view →
STAD	Male	II,III,IV	+2.749	<.001	10	view →
LUSC	All	II,III,IV	−2.882	<.001	8	view →
BRCA	Female	II,III,IV	+1.210	<.001	6	view →
LIHC	All	II,III,IV	+1.054	.002	6	view →
CHOL	All	All	+4.420	<.001	5	view →
READ	All	II,III,IV	−1.260	.019	1	view →
LUAD	Female	All	−0.811	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FOXJ1–KICH

Open the KICH breakdown →