Across TCGA patient cohorts, FOXI2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXI2-associated genes across cancer lineages are GAPDH, eEF2, and IGFBP2. Each is linked with FOXI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXI2-to-partner and partner-to-FOXI2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXI2→partner) and Y-score (partner→FOXI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.686	+3.321	.004	.009	3	2
UCEC	eEF2 →	+0.499	+3.169	.001	.019	3	1
UCEC	IGFBP2 →	-0.602	-3.000	.040	.036	3	1
UCEC	Notch1 →	+0.125	+2.000	.049	.032	3	1
UCEC	p62 Lck ligand →	+0.576	+3.331	<.001	.005	3	1
UCEC	p70-S6K_pT389 →	-0.171	-2.449	.046	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

FOXI2 survival (RNA) · tumor vs normal (RNA) · all FOXI2 data types