FOXI1

Across TCGA patient cohorts, FOXI1 mutation is significantly associated with the RNA expression of many other genes, with 1,004 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXI1-associated genes across cancer lineages are RPL22P6, SF3A3, and DRG1. Each is linked with FOXI1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXI1-to-partner and partner-to-FOXI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL22P6 grouped by FOXI1-low versus FOXI1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXI1→partner) and Y-score (partner→FOXI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL22P6 →	+0.061	+4.136	<.001	.008	3	3
UCEC	SF3A3 →	+0.497	+3.754	.002	<.001	3	3
UCEC	DRG1 →	+0.425	+2.649	.003	.005	3	3
UCEC	XRCC6 →	+0.572	+3.354	.002	.005	3	3
GBM	OR6C7P →	+0.078	+5.149	<.001	.007	3	2
LIHC	RNU6-840P →	+0.470	+5.186	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,004 associations by consensus.

RPL22P6 by FOXI1 expression — COAD

Explore this box plot interactively →