FOXI1

Across TCGA patient cohorts, FOXI1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXI1-associated genes across cancer lineages are ATM, 4E-BP1, and INPP4B. Each is linked with FOXI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXI1-to-partner and partner-to-FOXI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FOXI1-low versus FOXI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXI1→partner) and Y-score (partner→FOXI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.958	-3.000	<.001	.036	3	2
UCEC	4E-BP1 →	+0.438	+3.321	.002	.010	3	2
UCEC	INPP4B →	-0.353	-3.169	.037	.019	3	1
UCEC	PRDX1 →	-0.250	-3.000	.020	.036	3	1
UCEC	Tuberin →	+0.364	+2.817	.009	.036	3	1
SKCM	mTOR →	+0.235	+3.321	.042	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ATM by FOXI1 expression — UCEC

Explore this box plot interactively →