FOXI1

Across TCGA cell cohorts, FOXI1 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXI1-associated genes across cancer lineages are PROP1, PRAMEF33, and OR10Q1. Each is linked with FOXI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXI1-to-partner and partner-to-FOXI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by FOXI1-low versus FOXI1-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXI1→partner) and Y-score (partner→FOXI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PROP1 →	+0.080	+5.169	<.001	.004	3	1
BONE	PRAMEF33 →	+0.046	+5.169	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR10Q1 →	+0.041	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	RESP18 →	+0.021	+3.362	<.001	.007	3	1
LUNG_SCLC	RXFP2 →	+0.263	+4.044	<.001	.009	3	1
LUNG_SCLC	TRIML1 →	+0.192	+4.269	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PROP1 by FOXI1 expression — BONE

Explore this box plot interactively →