FOXH1

Across TCGA pan-cancer cohorts, FOXH1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of FOXH1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FOXH1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FOXH1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

KIRC, KIRP, and LUSC are the cancer types where FOXH1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOXH1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+0.128	<.001	8	view →
KIRP	All	All	+0.107	.003	8	view →
LUSC	All	All	+0.418	<.001	7	view →
COAD	Female	II,III,IV	−0.662	<.001	6	view →
BLCA	All	All	+0.519	.001	6	view →
UCEC	All	All	+0.470	<.001	6	view →
HNSC	All	All	+0.444	.004	6	view →
BRCA	All	III,IV	+0.298	<.001	6	view →
LUAD	Female	All	+0.147	<.001	6	view →
PAAD	Female	All	+0.855	.003	4	view →
STAD	All	All	+0.641	<.001	4	view →
CHOL	Female	All	+0.273	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

FOXH1–KIRC

Open the KIRC breakdown →