FOXG1

Across TCGA pan-cancer cohorts, FOXG1 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated FOXG1 data layer compared with 19 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher FOXG1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FOXG1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

THYM, UCEC, and KICH are the cancer types where FOXG1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	1.000	0.627	.003	36	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
PAAD	OS	Median	All	0.112	0.640	.004	12	view →
READ	OS	Median	III,IV	0.644	0.932	<.001	12	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
BLCA	OS	Median	II,III,IV	1.000	0.414	.041	6	view →
HNSC	OS	Median	IV	0.122	0.736	<.001	6	view →
LUAD	DFS	Median	All	0.298	0.682	.002	5	view →
LUSC	OS	Median	II,III,IV	0.225	0.617	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

FOXG1–THYM (OS)

Open the THYM breakdown →