FOXG1

Across TCGA cell cohorts, FOXG1 mutation is significantly associated with the RNA expression of many other genes, with 718 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXG1-associated genes across cancer lineages are SLC37A3, SMYD4, and KSR2. Each is linked with FOXG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXG1-to-partner and partner-to-FOXG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC37A3 grouped by FOXG1-low versus FOXG1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXG1→partner) and Y-score (partner→FOXG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC37A3 →	+0.450	+3.125	.009	.008	3	2
LARGE_INTESTINE	SMYD4 →	+0.669	+3.067	.001	.009	3	2
BLOOD_Leukemia	KSR2 →	+0.245	+3.762	.008	.001	3	2
BLOOD_Lymphoma	AVP →	+0.039	+5.794	<.001	<.001	3	2
LARGE_INTESTINE	SRRD →	+0.772	+3.169	.001	.009	3	1
LARGE_INTESTINE	ZNF106 →	+0.696	+3.087	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 718 associations by consensus.

SLC37A3 by FOXG1 expression — LARGE_INTESTINE

Explore this box plot interactively →